Estradiol is a sex hormone and one of three types of estrogen. It plays a crucial role in various physiological processes, particularly in the reproductive system.

In individuals with ovaries, estradiol is produced primarily in the ovaries, and its levels fluctuate throughout the menstrual cycle. It is responsible for the development and maintenance of secondary sexual characteristics, such as breast development and the regulation of the menstrual cycle. Estradiol also helps maintain bone density, regulate cholesterol levels, and has an impact on mood and cognitive function.

In individuals with testes, estradiol is produced in smaller quantities, mainly in the testes, and plays a role in the regulation of certain functions, including bone health and sexual function.

Who should take this test?

Testing estradiol levels may be necessary for cisgender women, transgender women, non-binary individuals, and gender-diverse people assigned female at birth. This is typically done to monitor reproductive health, assess fertility and assist with in vitro fertilization procedures, manage menopausal symptoms, or as part of gender-affirming hormone therapy.

Estradiol levels may also be tested in cisgender men, transgender men, and gender-diverse individuals assigned male at birth when there are specific health concerns, such as hormonal imbalances or in the context of gender-affirming hormone therapy.

Some intersex individuals may have unique hormone profiles, and estradiol testing can be relevant for managing their health and well-being.

What is included in this test?

This blood test measures:

• Estradiol

How will taking this test benefit me?

This test is a valuable tool for assessing fertility in individuals seeking to conceive. For others, early detection of hormonal imbalances can prevent the development of more severe symptoms or complications associated with these conditions. For those undergoing hormone therapy, it is a valuable tool for monitoring the effectiveness and safety of that therapy.